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Monofunctional Maleimide Platin (IV) Prodrugs

A prodrug approach was adopted to minimize exposure of body tissues to free oxaliplatin. A variety of oxaliplatin prodrug derivatives were designed to release free oxaliplatin in a site-directed manner within tumour tissue. They were tested for efficacy in cellular and xenograft models. One class of derivatives exhibited remarkable effects on survival...

Published: 05/07/2023

Category(s): Science > Biosciences > Cell Biology, Science > Biosciences > Molecular biology, Science > Therapeutics > Cancer Research, Science > Therapeutics > Drug Discovery, Science > Therapeutics > Pharmacology

Mouse Model with Epidermis-Specific Double Knockout of Braf and Raf1 Alleles

The skin is the largest organ of the body, it protects it from damage and hosts immune system cells. To function effectively as a barrier, the skin continually regenerates producing new cells to replace the old. If the regeneration process fails the skin may produce tumors. In addition, disruption to the immune barrier can lead to autoimmune or allergic...

Published: 16/04/2021

Category(s): Technology > Healthcare, Science > Biosciences > Cell Biology, Science > Biosciences > Immunology/Inflammation, Science > Therapeutics > Drug Discovery

Novel Therapeutic Strategy for Parkinson's Disease

Using our screening strategy we identified a new class of small molecules that binds simultaneously to monomeric and to membrane-bound alpha-synuclein. Moreover these molecules have a high affinity to Lipocalin 2 (Lcn2/NGAL). Lcn2 is a potent neurotoxic factor secreted by reactive astrocytes. Pilot data for our compound in a chronic progressive model...

Published: 05/07/2023

Category(s): Science > Biosciences > Cell Biology, Science > Biosciences > Molecular biology, Science > Biosciences > Neuroscience, Science > Therapeutics > Drug Discovery