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Monofunctional Maleimide Platin (IV) Prodrugs
A prodrug approach was adopted to minimize exposure of body tissues to free oxaliplatin. A variety of oxaliplatin prodrug derivatives were designed to release free oxaliplatin in a site-directed manner within tumour tissue. They were tested for efficacy in cellular and xenograft models. One class of derivatives exhibited remarkable effects on survival...
Published: 05/07/2023
Category(s): Science > Biosciences > Cell Biology, Science > Biosciences > Molecular biology, Science > Therapeutics > Cancer Research, Science > Therapeutics > Drug Discovery, Science > Therapeutics > Pharmacology
NKCC inhibitors for stroke
Stroke is the second leading cause of death and the leading cause of disability worldwide. 60 percent of those who suffer a stroke die or become dependent. The irrevocable harm caused by interrupting blood flow to the brain unfolds hours to days after the initial blockage, therefore, it is critical to identify early interventions that could reduce neuronal...
Published: 21/12/2022
Category(s): Science > Biosciences > Biotechnology, Science > Biosciences > Molecular biology, Science > Therapeutics > Drug Discovery, Science > Therapeutics > Pharmacology, Technology > Healthcare, Science > Biosciences > Neuroscience
Rapid Chemoenzymatic Glycosylation of Conjugates
For many eukaryotic proteins, processing by post-translational modifications such as glycosylation is a critical step for correct folding and achievement of biological activity. These modifications that occur naturally within eukaryotic cells have to be replicated when preparing peptides and proteins that are chemically synthesized or recombinantly-produced...
Published: 01/04/2021
Category(s): Science > Biosciences > Molecular biology, Science > Chemistry > Biochemistry
Novel Therapeutic Strategy for Parkinson's Disease
Using our screening strategy we identified a new class of small molecules that binds simultaneously to monomeric and to membrane-bound alpha-synuclein. Moreover these molecules have a high affinity to Lipocalin 2 (Lcn2/NGAL). Lcn2 is a potent neurotoxic factor secreted by reactive astrocytes. Pilot data for our compound in a chronic progressive model...
Published: 05/07/2023
Category(s): Science > Biosciences > Cell Biology, Science > Biosciences > Molecular biology, Science > Biosciences > Neuroscience, Science > Therapeutics > Drug Discovery
Mirror Image Microarrays
Microarrays are versatile and widely used tools for high-throughput screening methods. Conventional light-directed synthesis of microarrays is a relatively inefficient and expensive process that is wasteful of raw materials.Researchers at the University of Vienna, Faculty of Chemistry have improved existing synthesis methods by developing a unique flow...
Published: 05/07/2023
Category(s): Science > Biosciences > Biotechnology, Science > Biosciences > Molecular biology, Science > Chemistry > Biochemistry, Science > Therapeutics > Drug Discovery, Engineering > Biomedical
Auxiliary-assisted glycopeptide synthesis
For many eukaryotic proteins, processing by post-translational modifications such as glycosylation is a critical step for correct folding and achievement of biological activity. These modifications that occur naturally within eukaryotic cells have to be replicated when preparing peptides and proteins that are chemically synthesized or recombinantly-produced...
Published: 13/02/2019
Category(s): Science > Biosciences > Biotechnology, Science > Biosciences > Molecular biology, Science > Chemistry > Biochemistry
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