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Subunit vaccines consist of recombinant or synthetic antigens, such as peptides or protein fragments, which are carefully chosen from the mechanistic analysis of the disease progression. These vaccines offer considerable advantages over the traditional vaccines in terms of specificity, safety and cost of production. However, due to rapid degradation...

Published: 24/10/2021

Category(s): Science > Therapeutics > Pharmacology, Science > Chemistry > Biochemistry, Technology > Healthcare, Science > Therapeutics > Drug Discovery

Rapid Chemoenzymatic Glycosylation of Conjugates

For many eukaryotic proteins, processing by post-translational modifications such as glycosylation is a critical step for correct folding and achievement of biological activity. These modifications that occur naturally within eukaryotic cells have to be replicated when preparing peptides and proteins that are chemically synthesized or recombinantly-produced...

Published: 01/04/2021

Category(s): Science > Biosciences > Molecular biology, Science > Chemistry > Biochemistry

Freeze Substitution Device

Freeze substitution is a technique that is commonly used in biological sample analysis (e.g. bacteria, unicellular organisms, culture cells and tissues of both the animal and plant kingdoms). In order to improve sample preparation for electron microscopy (inclusively of analytical methods such as EDX, EELS, NanoSIMS) one initiates the process of substitution...

Published: 06/07/2021

Category(s): Science > Chemistry > Biochemistry, Engineering > Biomedical

Mirror Image Microarrays

Microarrays are versatile and widely used tools for high-throughput screening methods. Conventional light-directed synthesis of microarrays is a relatively inefficient and expensive process that is wasteful of raw materials.Researchers at the University of Vienna, Faculty of Chemistry have improved existing synthesis methods by developing a unique flow...

Published: 05/07/2023

Category(s): Science > Biosciences > Biotechnology, Science > Biosciences > Molecular biology, Science > Chemistry > Biochemistry, Science > Therapeutics > Drug Discovery, Engineering > Biomedical

Auxiliary-assisted glycopeptide synthesis

Published: 13/02/2019

Category(s): Science > Biosciences > Biotechnology, Science > Biosciences > Molecular biology, Science > Chemistry > Biochemistry

Procedure for the identification of aroma-active compounds (Bitterness Assay)

Many active pharmaceutical ingredients taste bitter and are thus aversive to children, many adults and animals, who may fail to comply with medication and complete their treatment. Encapsulation of bitter components is not an effective solution for children or anyone who has difficulties swallowing solid dose forms. The use of sugars or acids as taste-masking...

Published: 01/04/2021

Category(s): Science > Biosciences > Biotechnology, Science > Chemistry > Biochemistry, Science > Therapeutics > Pharmacology