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Monofunctional Maleimide Platin (IV) Prodrugs

A prodrug approach was adopted to minimize exposure of body tissues to free oxaliplatin. A variety of oxaliplatin prodrug derivatives were designed to release free oxaliplatin in a site-directed manner within tumour tissue. They were tested for efficacy in cellular and xenograft models. One class of derivatives exhibited remarkable effects on survival...

Published: 05/07/2023

Category(s): Science > Biosciences > Cell Biology, Science > Biosciences > Molecular biology, Science > Therapeutics > Cancer Research, Science > Therapeutics > Drug Discovery, Science > Therapeutics > Pharmacology