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Monofunctional Maleimide Platin (IV) Prodrugs

A prodrug approach was adopted to minimize exposure of body tissues to free oxaliplatin. A variety of oxaliplatin prodrug derivatives were designed to release free oxaliplatin in a site-directed manner within tumour tissue. They were tested for efficacy in cellular and xenograft models. One class of derivatives exhibited remarkable effects on survival...

Published: 05/07/2023

Category(s): Science > Biosciences > Cell Biology, Science > Biosciences > Molecular biology, Science > Therapeutics > Cancer Research, Science > Therapeutics > Drug Discovery, Science > Therapeutics > Pharmacology

Silaffin silica particle adjuvant

Subunit vaccines consist of recombinant or synthetic antigens, such as peptides or protein fragments, which are carefully chosen from the mechanistic analysis of the disease progression. These vaccines offer considerable advantages over the traditional vaccines in terms of specificity, safety and cost of production. However, due to rapid degradation...

Published: 24/10/2021

Category(s): Science > Therapeutics > Pharmacology, Science > Chemistry > Biochemistry, Technology > Healthcare, Science > Therapeutics > Drug Discovery

Novel scaffold for development of anticonvulsants

Epilepsy is one of the most common chronic neurological diseases worldwide. It is estimated that 1% of the world's population is affected by epilepsy during their lifetime with approximately 2.4 million new diagnosis being made each year. Although several anti-epileptic and anticonvulsant drugs are available for subscription, a significant number of...

Published: 02/04/2021

Category(s): Science > Biosciences > Neuroscience, Science > Therapeutics > Pharmacology, Technology > Healthcare

NKCC inhibitors for stroke

Stroke is the second leading cause of death and the leading cause of disability worldwide. 60 percent of those who suffer a stroke die or become dependent. The irrevocable harm caused by interrupting blood flow to the brain unfolds hours to days after the initial blockage, therefore, it is critical to identify early interventions that could reduce neuronal...

Published: 21/12/2022

Category(s): Science > Biosciences > Biotechnology, Science > Biosciences > Molecular biology, Science > Therapeutics > Drug Discovery, Science > Therapeutics > Pharmacology, Technology > Healthcare, Science > Biosciences > Neuroscience

Procedure for the identification of aroma-active compounds (Bitterness Assay)

Many active pharmaceutical ingredients taste bitter and are thus aversive to children, many adults and animals, who may fail to comply with medication and complete their treatment. Encapsulation of bitter components is not an effective solution for children or anyone who has difficulties swallowing solid dose forms. The use of sugars or acids as taste-masking...

Published: 01/04/2021

Category(s): Science > Biosciences > Biotechnology, Science > Chemistry > Biochemistry, Science > Therapeutics > Pharmacology