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Mouse Model with Epidermis-Specific Double Knockout of Braf and Raf1 Alleles

The skin is the largest organ of the body, it protects it from damage and hosts immune system cells. To function effectively as a barrier, the skin continually regenerates producing new cells to replace the old. If the regeneration process fails the skin may produce tumors. In addition, disruption to the immune barrier can lead to autoimmune or allergic...

Published: 16/04/2021

Category(s): Technology > Healthcare, Science > Biosciences > Cell Biology, Science > Biosciences > Immunology/Inflammation, Science > Therapeutics > Drug Discovery

Silaffin silica particle adjuvant

Subunit vaccines consist of recombinant or synthetic antigens, such as peptides or protein fragments, which are carefully chosen from the mechanistic analysis of the disease progression. These vaccines offer considerable advantages over the traditional vaccines in terms of specificity, safety and cost of production. However, due to rapid degradation...

Published: 24/10/2021

Category(s): Science > Therapeutics > Pharmacology, Science > Chemistry > Biochemistry, Technology > Healthcare, Science > Therapeutics > Drug Discovery

Novel scaffold for development of anticonvulsants

Epilepsy is one of the most common chronic neurological diseases worldwide. It is estimated that 1% of the world's population is affected by epilepsy during their lifetime with approximately 2.4 million new diagnosis being made each year. Although several anti-epileptic and anticonvulsant drugs are available for subscription, a significant number of...

Published: 02/04/2021

Category(s): Science > Biosciences > Neuroscience, Science > Therapeutics > Pharmacology, Technology > Healthcare

NKCC inhibitors for stroke

Stroke is the second leading cause of death and the leading cause of disability worldwide. 60 percent of those who suffer a stroke die or become dependent. The irrevocable harm caused by interrupting blood flow to the brain unfolds hours to days after the initial blockage, therefore, it is critical to identify early interventions that could reduce neuronal...

Published: 21/12/2022

Category(s): Science > Biosciences > Biotechnology, Science > Biosciences > Molecular biology, Science > Therapeutics > Drug Discovery, Science > Therapeutics > Pharmacology, Technology > Healthcare, Science > Biosciences > Neuroscience